Everything about Ariboflavinosis totally explained
Ariboflavinosis is the medical condition caused by deficiency of
riboflavin (vitamin B
2). Ariboflavinosis is most often seen in association with
protein-energy malnutrition, and also in cases of
alcoholism.
It was originally known as
pellagra sin pellagra, as it exhibits certain similarities to the
niacin deficiency
pellagra. The most common cause of riboflavin deficiency is an inadequate diet, thus it occurs most frequently in populations consuming limited quantities of riboflavin-containing foods such as
meats,
eggs,
milk,
cheese,
yogurt,
leafy green vegetables and
whole grains. Riboflavin deficiency can also occur in those with impaired
liver function, which prevents proper utilization of the vitamin. Borderline riboflavin deficiency as a consequence of certain
anti-retroviral medications has also been known to cause acute
lactic acidosis.
The signs and symptoms of riboflavin deficiency typically include sore throat with redness and swelling of the mouth and throat
mucosa,
cheilosis and angular
stomatitis (cracking of the lips and corners of the mouth),
glossitis (magenta tongue with atrophy),
seborrheic dermatitis or pseudo-syphilis (moist, scaly skin particularly affecting the
scrotum or
labia majora and the nasolabial folds), and a decreased
red blood cell count with normal cell size and
hemoglobin content (normochromic normocytic
anemia).
Riboflavin deficiency is usually found together with other nutrient deficiencies, particularly of the other water-soluble
vitamins.
Phototherapy to treat
jaundice in infants can cause increased degradation of riboflavin, leading to deficiency if not monitored closely. Persons with chronic alcoholism can have impaired absorption of riboflavin and other vitamins such as
thiamine (see
Wernicke's encephalopathy).
Studies of the
Turkoman people of
Iran, who have a significantly increased incidence of esophageal
cancer, have shown some relationship between chronic riboflavin deficiency and the onset of esophageal malignancies. One study of pregnant women has found that riboflavin-deficient women were 4.7 times more likely to develop
preeclampsia, though the mechanism for this isn't known.
The
US Recommended Daily Allowance (RDA) for riboflavin ranges from 1.1 to 1.3 milligrams per day for healthy adults to as high as 1.6 mg/day for pregnant or nursing women.
Further Information
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